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ToolsYamaji, Sachie, Tennant, Jason, Tandy, Sarah, Williams, Mark, Singh Srai, Surjit Kaila and Sharp, Paul (2001) Zinc regulates the function and expression of the iron transporters DMT1 and IREG1 in human intestinal Caco-2 cells. FEBS Letters, 507 (2). pp. 137-141. ISSN 1873-3468
Full text not available from this repository. (Request a copy)Abstract
Trace metals influence the absorption of each other from the diet and it has been suggested that the divalent metal transporter (DMT1) represents a common uptake pathway for these important micronutrients. However, compelling evidence from our laboratory suggests that DMT1 is predominantly an iron transporter, with lower affinity for other metals. Several studies have shown that increasing dietary iron downregulates DMT1. Interestingly, our current data indicate that zinc upregulates DMT1 protein and mRNA expression and also pH-dependent iron uptake. Transepithelial flux of iron was also increased and was associated with a rise in IREG1 mRNA expression.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 07 Mar 2011 13:31 |
| Last Modified: | 15 Dec 2022 01:52 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/25697 |
| DOI: | 10.1016/S0014-5793(01)02953-2 |
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