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Tucker, Nicholas P., Le Brun, Nick E. 
ORCID: https://orcid.org/0000-0001-9780-4061, Dixon, Ray and Hutchings, Matthew I.
(2010)
There's NO stopping NsrR, a global regulator of the bacterial NO stress response.
Trends in Microbiology, 18 (4).
pp. 149-156.
ISSN 1878-4380
Abstract
Nitric oxide (NO) is a toxic, free radical gas with diverse biological roles in eukaryotes and bacteria, being involved in signalling, vasodilation, blood clotting and immunity and as an intermediate in microbial denitrification. Several bacterial transcriptional regulators sense this molecule and regulate the expression of genes involved in both NO detoxification and NO damage repair. However, a recently discovered NO sensing repressor, named NsrR, has gained attention because of its suggested role as a global regulator of the bacterial NO stress response. Recent advances in biochemical and transcriptomic studies of NsrR make it timely to review the current evidence for NsrR as a global regulator and to speculate on the recent controversy over its NO sensing mechanism.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Chemistry (former - to 2024) Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences Faculty of Science > Research Groups > Organisms and the Environment Faculty of Science > Research Groups > Molecular Microbiology |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 01 Mar 2011 13:29 |
| Last Modified: | 24 Sep 2024 09:09 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/25406 |
| DOI: | 10.1016/j.tim.2009.12.009 |
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