Phase I study of STX 64 (667 Coumate) in breast cancer patients: The first study of a steroid sulphatase inhibitor

Stanway, Susannah J., Purohit, Atul, Woo, L. W. Lawrence, Sufi, Saulat, Vigushin, David, Ward, Rebecca, Wilson, Richard H., Stanczyk, Frank Z., Dobbs, Nicola, Kulinskaya, Elena, Elliott, Moira, Potter, Barry V. L., Reed, Michael J. and Coombes, R. Charles (2006) Phase I study of STX 64 (667 Coumate) in breast cancer patients: The first study of a steroid sulphatase inhibitor. Clinical Cancer Research, 12 (5). pp. 1585-1592. ISSN 1078-0432

Full text not available from this repository. (Request a copy)

Abstract

Purpose: Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. Experimental Design: STX64 (667 Coumate), a tricylic coumarin-based sulfamate that irreversibly inhibits STS activity, was selected for entry into the first phase I trial of a STS inhibitor in postmenopausal women with breast cancer. STX64 was administered orally (nine patients at 5 mg and five patients at 20 mg) as an initial dose followed 1 week later by 3 × 2 weekly cycles, with each cycle comprising daily dosing for 5 days followed by 9 days off treatment. Blood and tumor tissue samples were collected for the assessment of STS activity and serum was obtained for steroid hormone measurements before and after treatment. Results: The median inhibition of STS activity by STX64 was 98% in peripheral blood lymphocytes (PBL) and 99% in breast tumor tissue at the end of the 5-day dosing period. As expected, serum concentrations of estrone, estradiol, androstenediol, and DHEA all decreased significantly from pretreatment levels. Unexpectedly, androstenedione and testosterone concentrations also decreased. Four patients, all of whom had previously progressed on aromatase inhibitors, showed evidence of stable disease for 2.75 to 7 months. The drug was well tolerated with only minor drug-related adverse events recorded. Conclusion: STX64 is a potent, well-tolerated STS inhibitor. It inhibits STS activity in PBLs and tumor tissues and causes significant decreases in serum concentrations of steroids with estrogenic properties.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Computing Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Data Science and Statistics Faculty of Medicine and Health Sciences > Research Centres > Business and Local Government Data Research Centre (former - to 2023) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	Vishal Gautam
Date Deposited:	09 Mar 2011 09:27
Last Modified:	30 Jun 2023 13:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/23753
DOI:	10.1158/1078-0432.CCR-05-1996

Actions (login required)

View Item