Association between carotid artery intima-media thickness and cardiovascular risk factors in CKD

Preston, Emma, Ellis, Mary R., Kulinskaya, Elena, Davies, Alun H. and Brown, Edwina A. (2005) Association between carotid artery intima-media thickness and cardiovascular risk factors in CKD. American Journal of Kidney Diseases, 46 (5). pp. 856-862. ISSN 0272-6386

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Abstract

Background: Common carotid artery intima-media thickness (CCA-IMT) correlates with cardiovascular events in the general population and is an independent predictor of cardiovascular mortality in the hemodialysis population. It has not been evaluated extensively in patients with chronic kidney disease. Methods: CCA-IMT was measured by using high-resolution B-mode ultrasonography, and glomerular filtration rate (GFR) was measured by means of EDTA clearance. Cardiovascular risk factors assessed included homocysteine and lipoprotein(a) levels, as well as smoking, blood pressure, and cholesterol level. Results: One hundred fourteen patients were studied; mean measured GFR was 29.6 ± 18.4 mL/min/1.73 m2 (0.49 ± 0.31 mL/s). CCA-IMT was significantly elevated (0.59 ± 0.22 cm) compared with a control group (0.44 ± 0.08 cm; P = 0.0012). CCA-IMT increases with age (P < 0.0001) and low-density lipoprotein level (P = 0.048) and decreases with high-density lipoprotein level (P = 0.001) and being white (P = 0.014). Conclusion: This study suggests that arterial changes occur early in the course of renal disease progression and may be related to dyslipidemia in the early stages.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Computing Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Business and Local Government Data Research Centre (former - to 2023) Faculty of Science > Research Groups > Data Science and Statistics Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	Vishal Gautam
Date Deposited:	20 Jul 2011 13:51
Last Modified:	01 Feb 2024 02:17
URI:	https://ueaeprints.uea.ac.uk/id/eprint/23607
DOI:	10.1053/j.ajkd.2005.07.048

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