Effects of Spatial Growth on Gene Expression Dynamics and on Regulatory Network Reconstruction

Kim, J. T. (2005) Effects of Spatial Growth on Gene Expression Dynamics and on Regulatory Network Reconstruction. In: Advances in Artificial Life. Lecture Notes in Computer Science, 3630 . Springer, pp. 825-834. ISBN 978-3-540-28848-0

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Abstract

Morphogenesis and the spatial structure of an organism have repercussions on gene expression. These effects can influence the results of regulatory network reconstruction. An integrated, flexible and extensible computational framework for modelling gene expression dynamics within spatially growing structures is developed and used as a test system for evaluating a reconstruction algorithm. With complex morphological structures, significant effects of spatial organisation on the reconstruction process are observed. The results also reveal that stronger regulatory interactions result in more frequent cases of indirect regulation, posing a challenge for accurate network reconstruction.

Item Type:	Book Section
Additional Information:	Proceedings of the 8th European Conference, ECAL 2005, Canterbury, UK, September 5-9, 2005
Faculty \ School:	Faculty of Science > School of Computing Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Computational Biology
Depositing User:	Vishal Gautam
Date Deposited:	20 Jul 2011 12:59
Last Modified:	22 Apr 2023 02:37
URI:	https://ueaeprints.uea.ac.uk/id/eprint/22511
DOI:	10.1007/11553090_83

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