Porphyrin self-assembled monolayers and photodynamic oxidation of tryptophan

Chambrier, Isabelle, Russell, David A., Brundish, Derek E., Love, William G., Jori, Giulio, Magaraggia, M. and Cook, Michael J. (2010) Porphyrin self-assembled monolayers and photodynamic oxidation of tryptophan. Journal of Porphyrins and Phthalocyanines, 14 (01). pp. 81-88. ISSN 1088-4246

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Abstract

The zinc and magnesium metalated derivatives of 5,5'-[12,12'-di(thiododecyloxy)-4,4'-phenyl)]-10,10',15,15',20,20'-hexakis(3,3',4,4',5,5'-hexakisdecyloxyphenyl)diporphyrin, 1b and 1c, have been synthesised and deposited to form self-assembled monolayer (SAM) films on the surface of gold-coated glass substrates. The SAM films have been characterized by RAIR spectroscopy and fluorescence spectroscopy. The potential for the porphyrin films to catalyze the oxidation of tryptophan within human serum albumin upon irradiation with white light has been demonstrated and attributed to the porphyrins acting as photosensitizers of oxygen to form oxidizing species.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017)
Depositing User:	Rachel Smith
Date Deposited:	24 Jan 2011 12:14
Last Modified:	24 Sep 2024 09:11
URI:	https://ueaeprints.uea.ac.uk/id/eprint/19772
DOI:	10.1142/S1088424610001696

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