A mathematical model of the indirect effects of rotavirus vaccination

Van Effelterre, T., Soriano-Gabarro, M., Debrus, S., Claire Newbern, E. and Gray, J. J. (2010) A mathematical model of the indirect effects of rotavirus vaccination. Epidemiology and Infection, 138 (6). pp. 884-897. ISSN 1469-4409

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Abstract

Rotavirus (RV) infections progressively confer natural immunity against subsequent infection. Similarly to natural infection, vaccination with a live attenuated vaccine potentially reduces RV transmission and induces herd protection. A mathematical transmission model was developed to project the impact of a vaccination programme on the incidence of RV infection and disease for five countries in the European Union. With vaccination coverage rates of 70%, 90% and 95% the model predicted that, in addition to the direct effect of vaccination, herd protection induced a reduction in RV-related gastroenteritis (GE) incidence of 25%, 22% and 20%, respectively, for RV-GE of any severity, and of 19%, 15%, and 13%, respectively, for moderate-to-severe RV-GE, 5 years after implementation of a vaccination programme.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	21 Mar 2024 15:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15633
DOI:	10.1017/S0950268809991245

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