Comparative value of NYHA Functional Class and Quality-of-Life Questionnaire scores in assessing heart failure

Athanasopoulos, Leonidas V., Dritsas, Athanasios, Doll, Helen and Cokkinos, Dennis V. (2010) Comparative value of NYHA Functional Class and Quality-of-Life Questionnaire scores in assessing heart failure. Journal of Cardiopulmonary Rehabilitation & Prevention, 30 (2). pp. 101-105. ISSN 1932-751X

Full text not available from this repository.

Abstract

PURPOSE: To assess the relationships between New York Heart Association (NYHA) functional class, quality of life, aerobic capacity (peak oxygen uptake, V̇O2), ventilatory efficiency (minute ventilation/carbon dioxide production slope, VE/V̇CO2 slope), and brain natriuretic peptide (BNP) in creating a model for predicting peak V̇O2. METHODS: Cardiopulmonary exercise testing was performed in 62 patients. A baseline blood sample was taken to measure the N-terminal prohormone BNP (NT-proBNP). Patients also completed the Minnesota Living with Heart Failure Questionnaire (MLHF) and the Specific Activity Questionnaire (SAQ), and NYHA functional class was determined. RESULTS: NYHA functional class correlated more strongly with SAQ score than with MLHF score. Peak V̇O2 and VE/V̇CO2 slope had stronger associations with NYHA functional class and SAQ score than with MLHF score. NT-proBNP plasma levels correlated more significantly with NYHA functional class and SAQ score (both P < .001) than with MLHF score. Using multiple linear regression analysis adjusted for age and sex, SAQ score, NT-proBNP, and etiology of heart failure had significant independent relationships with peak V̇O2, explaining 63% of its variability (adjusted R2 = 0.596). CONCLUSIONS : Cardiopulmonary exercise variables and plasma NT-proBNP are associated more with NYHA functional class and SAQ score than with MLHF score. When combined, SAQ score, NT-proBNP, and etiology of heart failure can satisfactorily predict peak oxygen uptake.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	12 Jan 2024 01:21
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15587
DOI:	10.1097/HCR.0b013e3181be7e47

Actions (login required)

View Item