Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity

Davos, Constantinos H., Doehner, Wolfram, Rauchhaus, Mathias, Cicoira, Mariantonietta, Francis, Darrel P., Coats, Andrew J. S., Clark, Andrew L. and Anker, Stefan D. (2003) Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity. Journal of Cardiac Failure, 9 (1). pp. 29-35. ISSN 1532-8414

Full text not available from this repository.

Abstract

Background: Cachexia in chronic heart failure carries a poor prognosis, but little is known about the influence of body mass on the prognosis of noncachectic heart failure patients. Methods: We studied 589 consecutive chronic heart failure patients followed for at least a year, in whom there were accurate baseline data for body mass. Results: Average age was 64.5 ± 12.4 years, left ventricular ejection fraction (LVEF) 30.9 ± 0.73%. Cachexia was present in 64. Noncachectic patients were divided into quintiles of body mass index (BMI), Q1 (BMI 22.2 ± 1.5) to Q5 (BMI 34.1 ± 2.8). There was no difference among the 5 groups in age, exercise capacity or LVEF. Survival was greatest in Q4 (1-year survival [95% confidence interval (CI)]) 0.91 (0.85–0.96) and 3-year survival 0.81 (0.73–0.89). Relative risks compared with Q4 were Q1: 2.3 (1.4–3.8); Q2: 1.7 (1.1–2.9); Q3: 1.8 (1.1–3.0); and Q5: 1.5 (0.9–2.5). In multivariate analysis of 1 year follow-up, peak oxygen consumption (hazard ratio with 95% CI) (0.89 [0.82–0.97]; P =.006), LVEF (0.94 [0.91–0.97]; P =.0002) and BMI (0.90 [0.82–0.98]; P =.02) independently predicted 1-year survival with a combined X2 value of 42.4. Age (1.01 [0.98–1.05] and diagnosis (1.56 [0.78–3.11]) was not a predictor of survival. Conclusion: In patients with chronic heart failure, increasing BMI is not an adverse prognostic feature. Thinner patients appear to have a poorer prognosis.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	21 Dec 2023 01:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15554
DOI:	10.1054/jcaf.2003.4

Actions (login required)

View Item