Evidence that bone mineral density plays a role in degenerative disc disease: the UK Twin Spine study

Livshits, Gregory, Ermakov, Sergey, Popham, Maria, MacGregor, Alex J. ORCID: https://orcid.org/0000-0003-2163-2325, Sambrook, Philip N., Spector, Timothy D. and Williams, Frances M. K. (2010) Evidence that bone mineral density plays a role in degenerative disc disease: the UK Twin Spine study. Annals of the Rheumatic Diseases, 69 (12). pp. 2102-2106. ISSN 0003-4967

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Abstract

Osteoarthritis (OA) and osteoporosis are often considered to lie at opposite ends of a spectrum of bone phenotypes. Lumbar degenerative disc disease (LDD) may be associated with low back pain (LBP) and is similar in many ways to OA. LDD is reported in small studies to be associated with increased spine bone mineral density (BMD). The present work aimed to confirm this association in a large population sample using MRI and explore the relationship further, in particular to determine whether it is mediated genetically.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,aged,aged, 80 and over,bone density,diseases in twins,epidemiologic methods,female,genetic predisposition to disease,hip joint,humans,intervertebral disc degeneration,lumbar vertebrae,magnetic resonance imaging,middle aged,young adult
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	24 Sep 2024 09:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15342
DOI:	10.1136/ard.2010.131441

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