Meta-analysis of the comparative efficacy and safety of adjuvant treatment to Levodopa in later Parkinson's disease

Stowe, Rebecca, Ives, Natalie, Clarke, Carl E., Handley, Kelly, Furmston, Alexandra, Deane, Katherine ORCID: https://orcid.org/0000-0002-0805-2708, Van Hilten, J. J., Wheatley, Keith and Gray, Richard (2011) Meta-analysis of the comparative efficacy and safety of adjuvant treatment to Levodopa in later Parkinson's disease. Movement Disorders, 26 (4). pp. 587-598. ISSN 0885-3185

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Abstract

Levodopa initially provides good symptomatic control of the symptoms of Parkinson's disease, but motor complications often develop after long-term use. Other classes of antiparkinsonian drugs including dopamine agonists, catechol-O-methyl transferase inhibitors, or monoamine oxidase type B inhibitors are then added as adjuvant therapy. It is unclear whether one class of drug is more effective than another. This meta-analysis evaluates the comparative benefits and risks of these agents as adjuvant treatment in Parkinson's disease patients with motor complications.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Nursing and Midwifery
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	23 Oct 2022 00:44
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15244
DOI:	10.1002/mds.23517

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