Meta-analysis of the comparative efficacy and safety of adjuvant treatment to Levodopa in later Parkinson's disease

Stowe, Rebecca, Ives, Natalie, Clarke, Carl E., Handley, Kelly, Furmston, Alexandra, Deane, Katherine, Van Hilten, J. J., Wheatley, Keith and Gray, Richard (2011) Meta-analysis of the comparative efficacy and safety of adjuvant treatment to Levodopa in later Parkinson's disease. Movement Disorders, 26 (4). pp. 587-598. ISSN 0885-3185

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Abstract

Levodopa initially provides good symptomatic control of the symptoms of Parkinson's disease, but motor complications often develop after long-term use. Other classes of antiparkinsonian drugs including dopamine agonists, catechol-O-methyl transferase inhibitors, or monoamine oxidase type B inhibitors are then added as adjuvant therapy. It is unclear whether one class of drug is more effective than another. This meta-analysis evaluates the comparative benefits and risks of these agents as adjuvant treatment in Parkinson's disease patients with motor complications.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Nursing and Midwifery (former - to 2011)
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health in Later Life (former - to 2017) Faculty of Medicine and Health Sciences > Research Groups > Community and Family Health (former - to 2017) Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	06 Feb 2025 01:41
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15244
DOI:	10.1002/mds.23517

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