Combined effect of health behaviours and risk of first ever stroke in 20,040 men and women over 11 years's follow-up in Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): prospective population study

Myint, Phyo K., Luben, Robert N., Wareham, Nicholas J., Bingham, Sheila A. and Khaw, Kay-Tee (2009) Combined effect of health behaviours and risk of first ever stroke in 20,040 men and women over 11 years's follow-up in Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): prospective population study. BMJ-British Medical Journal, 338. ISSN 0959-8138

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Abstract

Objective: To quantify the potential combined impact of four health behaviours on incidence of stroke in men and women living in the general community. Design: Population based prospective study (EPIC-Norfolk). Setting: Norfolk, United Kingdom. Participants: 20 040 men and women aged 40-79 with no known stroke or myocardial infarction at baseline survey in 1993-7, living in the general community, and followed up to 2007. Main outcome measure: Participants scored one point for each health behaviour: current non-smoking, physically not inactive, moderate alcohol intake (1-14 units a week), and plasma concentration of vitamin C ≥50 µmol/l, indicating fruit and vegetable intake of at least five servings a day, for a total score ranging from 0 to 4. Results: There were 599 incident strokes over 229 993 person years of follow-up; the average follow-up was 11.5 years. After adjustment for age, sex, body mass index (BMI), systolic blood pressure, cholesterol concentration, history of diabetes and aspirin use, and social class, compared with people with the four health behaviours the relative risks for stroke for men and women were 1.15 (95% confidence interval 0.89 to 1.49) for three health behaviours, 1.58 (1.22 to 2.05) for two, 2.18 (1.63 to 2.92) for one, and 2.31 (1.33 to 4.02) for none (P<0.001 for trend). The relations were consistent in subgroups stratified by sex, age, body mass index, and social class, and after exclusion of deaths within two years. Conclusion: Four health behaviours combined predict more than a twofold difference in incidence of stroke in men and women.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:13
Last Modified:	24 Sep 2024 09:24
URI:	https://ueaeprints.uea.ac.uk/id/eprint/15055
DOI:	10.1136/bmj.b349

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