Perspectives on the Trypanosoma cruzi-host cell receptor interaction

Villalta, Fernando, Scharfstein, Julio, Ashton, Anthony W., Tyler, Kevin M. ORCID:, Guan, Fangxia, Mukherjee, Shankar, Lima, Maria F., Alvarez, Sandra, Weiss, Louis M., Huang, Huan, Machado, Fabiana S. and Tanowitz, Herbert B. (2009) Perspectives on the Trypanosoma cruzi-host cell receptor interaction. Parasitology Research, 104 (6). pp. 1251-1260.

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Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:12
Last Modified: 24 Oct 2022 00:32
DOI: 10.1007/s00436-009-1383-3

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