Flagellar elongation induced by glucose limitation is preadaptive for Trypanosoma cruzi differentiation

Tyler, Kevin M. ORCID: https://orcid.org/0000-0002-0647-8158 and Engman, David M. (2000) Flagellar elongation induced by glucose limitation is preadaptive for Trypanosoma cruzi differentiation. Cell Motility and the Cytoskeleton, 46 (4). pp. 269-278. ISSN 0886-1544

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Abstract

Trypanosomes must sense and respond to environmental change in order to progress through their life cycles. The American trypanosome, Trypanosoma cruzi, differentiates from the noninfective epimastigote form to the infective metacyclic form spontaneously in axenic culture. Here, we investigate the initial stimulus for that change and demonstrate that T. cruzi epimastigotes sense limitation of glucose in the medium and respond by undergoing significant morphological and biochemical change. As part of this change, the mean flagellar length of the population triples, which is correlated with an increased ability to maintain interactions with hydrophobic substrates, a requirement for differentiation to the next life cycle stage.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:12
Last Modified:	24 Sep 2024 10:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/14730
DOI:	10.1002/1097-0169(200008)46:4<269::AID-CM4>3.0.CO;2-V

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