Impact of pregnancy on the progression of diabetic retinopathy in Type 1 diabetes

Temple, R. C., Aldridge, V. A., Sampson, M. J., Greenwood, R. H., Heyburn, P. J. and Glenn, A. (2001) Impact of pregnancy on the progression of diabetic retinopathy in Type 1 diabetes. Diabetic Medicine, 18 (7). pp. 573-577. ISSN 1464-5491

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Abstract

Aims: To evaluate the impact of pregnancy on the progression of diabetic retinopathy in women with Type 1 diabetes mellitus and to identify risk factors for the progression of retinopathy during pregnancy. Methods: One hundred and seventy-nine pregnancies in 139 women with pregestational Type 1 diabetes were studied prospectively between January 1990 and December 1998. Dilated fundal examination was performed at booking, 24 weeks and 34 weeks or 4–6 weekly if retinopathy present at booking. Data were collected on glycaemic control (HbA1c) throughout pregnancy. Results: Progression to proliferative retinopathy was seen in four (2.2%) pregnancies while moderate progression was seen in a further five (2.8%) pregnancies. Progression of retinopathy was significantly increased in women with duration of diabetes 10–19 years compared with duration < 10 years (10% vs. 0%; P = 0.007) and in women with moderate to severe background retinopathy at booking (30% vs. 3.7%; P = 0.01). Although HbA1c at booking was higher (7.5% vs. 6.6%; P = 0.08) and the fall in HbA1c between booking and 24 weeks was greater (1.6% vs. 1.2%; P = 0.2) in those women showing progression of retinopathy, these changes were not significant. Conclusions: Progression of retinopathy in pregnancy was uncommon (5.0% pregnancies) but was significantly more common in women with duration of diabetes > 10 years and in women with moderate to severe retinopathy at baseline. Laser therapy was needed in 2.2% pregnancies, which is much lower than that reported in earlier studies.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:11
Last Modified:	23 Oct 2022 21:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13839
DOI:	10.1046/j.1464-5491.2001.00535.x

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