Porcine gd T-cells: Possible roles on the innate and adaptive immune responses following virus infection

Takamatsu, H.-H., Denyer, M. S., Stirling, C., Cox, S., Aggarwal, N., Dash, P., Wileman, T. E. and Barnett, P. V. (2006) Porcine gd T-cells: Possible roles on the innate and adaptive immune responses following virus infection. Veterinary Immunology and Immunopathology, 112 (1-2). pp. 49-61. ISSN 1873-2534

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Abstract

γδ T cells recognise different types of antigen in alternative ways to αβ T cells, and thus appear to play a complementary role in the immune response. However, unlike αβ T cells, the role or function of γδ T cells is still unclear. As pigs possess a high proportion of circulating γδ T cells, they are suitable large animal model to study γδ T cell functions. This as yet has not been fully exploited, leaving porcine γδ T cell biology and its role in immunity in its infancy. Foot-and-mouth disease (FMD) high potency “emergency” vaccines are able to induce early protection from challenge and it has been suggested that, in part, there is some involvement of innate immune responses. The antigen component of the vaccine is able to stimulate purified naïve pig γδ T cells and induce the mRNA of various cytokines and chemokines. This observation suggests that γδ T cells probably contribute to the early phase of the immune responses to FMD vaccination, and perhaps infection. A subset of these circulating γδ T cells display a phenotype similar to professional antigen presenting cells and are able to take up and present soluble antigen to CD4+ T cells in a direct cell–cell interaction via MHC class II. This direct interaction between γδ T cells and CD4+ T cells is likely to have a significant influence on the out come of the adaptive immune response.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:11
Last Modified:	12 Jun 2024 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13821
DOI:	10.1016/j.vetimm.2006.03.011

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