Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort

Skidmore, Paula M. L., Cassidy, Aedin, Swaminathan, Ramasamyiyer, Richards, J. Brent, Spector, Tim D. and MacGregor, Alex J. ORCID: https://orcid.org/0000-0003-2163-2325 (2008) Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort. The Journal of Clinical Endocrinology and Metabolism, 93 (2). pp. 516-520. ISSN 0021-972X

Full text not available from this repository. (Request a copy)

Abstract

Because an adverse intrauterine environment is thought to induce insulin resistance, our objective was to investigate the relationships between birth weight, BMI, and change in body size over the life course and insulin resistance. SETTING, DESIGN, AND PARTICIPANTS: We conducted a cross-sectional study in a cohort of 1194 female twins aged 18-74 yr. The relationship between birth weight and insulin resistance was analyzed using a regression method allowing for a simultaneous estimation of within- and between-pair influences. The approach allows the influence of individual fetal nutrition on adult insulin resistance to be distinguished from effects that are mediated by confounding factors in the maternal environment.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,aged,birth weight,blood glucose,body mass index,cohort studies,cross-sectional studies,female,humans,infant, newborn,insulin,insulin resistance,linear models,middle aged,twins, dizygotic,twins, monozygotic
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:11
Last Modified:	22 Apr 2023 01:08
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13698
DOI:	10.1210/jc.2007-1424

Actions (login required)

View Item