Reduced beta-cell function in offspring of mothers with young-onset type 2 diabetes

Singh, R., Pearson, E., Avery, P. J., McCarthy, M., Levy, J., Hitman, G., Sampson, M. J., Walker, M. and Hattersley, A. T. (2006) Reduced beta-cell function in offspring of mothers with young-onset type 2 diabetes. Diabetologia, 49 (8). pp. 1876-1880.

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Abstract

Animal models indicate that even exposure to mild maternal hyperglycaemia in utero is detrimental to the beta cell function of the offspring, but evidence of this in humans is limited. In Europids who are diagnosed with type 2 diabetes before the age of 50 years, the risk of diabetes in the offspring of the diabetic mothers is greatly increased compared with the risk in those born to diabetic fathers. We hypothesised that offspring born to mothers with young-onset type 2 diabetes would have been exposed to mild hyperglycaemia in utero, so we studied the impact of this on their beta cell function.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:11
Last Modified:	24 Oct 2022 04:20
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13690
DOI:	10.1007/s00125-006-0285-5

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