Newborn screening for cystic fibrosis is associated with reduced treatment intensity

Sims, Erika J., McCormick, Jonathan, Mehta, Gita and Mehta, Anil (2005) Newborn screening for cystic fibrosis is associated with reduced treatment intensity. Pediatrics, 147 (3). pp. 306-311. ISSN 1098-4275

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Abstract

Objectives: To determine whether the improved clinical status after newborn screening (NBS) for cystic fibrosis (CF) segregates with increased therapeutic intervention compared with presentation by clinical diagnosis (CD). Study design: In 2002, two populations (1 to 9 years of age) who presented (excluding meconium ileus) by NBS ≤3 months of age or by CD were compared in an observational, cross-sectional design. NBS and CD populations (184 and 950 patients, respectively) were divided into 3-year age groups (1 to 3, 4 to 6, and 7 to 9 years). Therapies of duration >3 months were compared together with Pseudomonas aeruginosa infection status. Results: NBS patients ≤6 years of age received significantly fewer and less demanding therapies not explained by age, genotype, geography, or social deprivation. In 7- to 9-year-olds, significantly fewer NBS patients received intravenous antibiotics. NBS patients without P aeruginosa infection received significantly fewer therapies, but no differences were found between intermittently or chronically infected NBS and CD populations. Comparable results were found in ΔF508/ΔF508 subpopulations. Conclusions: CF populations diagnosed by NBS are associated with reduced treatment compared with age- and genotype-matched CD control subjects.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:11
Last Modified:	28 Mar 2025 04:16
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13684
DOI:	10.1016/j.jpeds.2005.05.034

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