Newborn screening for cystic fibrosis is associated with reduced treatment intensity

Sims, Erika J. ORCID: https://orcid.org/0000-0002-7898-0331, McCormick, Jonathan, Mehta, Gita and Mehta, Anil (2005) Newborn screening for cystic fibrosis is associated with reduced treatment intensity. Pediatrics, 147 (3). pp. 306-311.

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Abstract

Objectives: To determine whether the improved clinical status after newborn screening (NBS) for cystic fibrosis (CF) segregates with increased therapeutic intervention compared with presentation by clinical diagnosis (CD). Study design: In 2002, two populations (1 to 9 years of age) who presented (excluding meconium ileus) by NBS ≤3 months of age or by CD were compared in an observational, cross-sectional design. NBS and CD populations (184 and 950 patients, respectively) were divided into 3-year age groups (1 to 3, 4 to 6, and 7 to 9 years). Therapies of duration >3 months were compared together with Pseudomonas aeruginosa infection status. Results: NBS patients ≤6 years of age received significantly fewer and less demanding therapies not explained by age, genotype, geography, or social deprivation. In 7- to 9-year-olds, significantly fewer NBS patients received intravenous antibiotics. NBS patients without P aeruginosa infection received significantly fewer therapies, but no differences were found between intermittently or chronically infected NBS and CD populations. Comparable results were found in ΔF508/ΔF508 subpopulations. Conclusions: CF populations diagnosed by NBS are associated with reduced treatment compared with age- and genotype-matched CD control subjects.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:11
Last Modified:	16 Jun 2024 06:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13684
DOI:	10.1016/j.jpeds.2005.05.034

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