Effect of sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells

Shan, Yujuan, Sun, Changhao, Zhao, Xiujuan, Wu, Kun, Cassidy, Aedin and Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 (2006) Effect of sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells. International Journal of Oncology, 29 (4). pp. 883-888.

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Abstract

Isothiocyanates (ITCs) from cruciferous vegetables have been shown to be effective in blocking initiation as well as progression of a range of chemically-induced tumors in animal models. In this study, sulforaphane, the most extensively studied ITC, was found to suppress the growth of T24 bladder cancer cells in vitro in a dose-dependent manner. Sulforaphane inhibited the proliferation of T24 cells with IC50 values 26.9 and 15.9 µM following 24 and 48 h treatments. Sulforaphane (5-20 µM) induced early apoptosis and blocked cell cycle progression at G0/G1 phase which was associated with upregulation of cyclin-dependent kinase inhibitor p27 expression. These results support a role for sulforaphane as an effective agent in the chemoprevention of bladder cancer.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:11
Last Modified:	13 Nov 2023 16:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13649
DOI:	10.3892/ijo.29.4.883

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