In vitro trypanocidal activity of the anti-helminthic drug nichlosamide

Merschjohann, Karin and Steverding, Dietmar (2008) In vitro trypanocidal activity of the anti-helminthic drug nichlosamide. Experimental Parasitology, 118 (4). pp. 637-640. ISSN 1090-2449

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Only a few drugs are available for chemotherapy of African trypanosomiasis and there is an urgent need for the development of new anti-trypanosomal agents. In this study, the anti-helminthic drug niclosamide was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei brucei and Trypanosoma congolense. The concentrations of niclosamide to reduce the growth rate by 50% and to kill all cells were in the low- and mid micromolar ranges for T. b. brucei and T. congolense, respectively. The very low toxicity of niclosamide for mammals makes the compound interesting for drug development for African trypanosomiasis.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: EPrints Services
Date Deposited: 25 Nov 2010 11:10
Last Modified: 24 Jan 2023 10:30
DOI: 10.1016/j.exppara.2007.12.001

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