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ToolsMerschjohann, Karin and Steverding, Dietmar (2008) In vitro trypanocidal activity of the anti-helminthic drug nichlosamide. Experimental Parasitology, 118 (4). pp. 637-640. ISSN 1090-2449
Full text not available from this repository. (Request a copy)Abstract
Only a few drugs are available for chemotherapy of African trypanosomiasis and there is an urgent need for the development of new anti-trypanosomal agents. In this study, the anti-helminthic drug niclosamide was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei brucei and Trypanosoma congolense. The concentrations of niclosamide to reduce the growth rate by 50% and to kill all cells were in the low- and mid micromolar ranges for T. b. brucei and T. congolense, respectively. The very low toxicity of niclosamide for mammals makes the compound interesting for drug development for African trypanosomiasis.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology |
| Depositing User: | EPrints Services |
| Date Deposited: | 25 Nov 2010 11:10 |
| Last Modified: | 24 Jan 2023 10:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/13256 |
| DOI: | 10.1016/j.exppara.2007.12.001 |
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