Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

Low, Yen-Ling, Taylor, James I., Grace, Philip B., Mulligan, Angela A., Welch, Ailsa A., Scollen, Serena, Dunning, Alison M., Luben, Robert N., Khaw, Kay-Tee, Day, Nick E., Wareham, Nick J. and Bingham, Sheila A. (2006) Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk. Nutrition and Cancer, 56 (1). pp. 31-39. ISSN 1532-7914

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Abstract

Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P

Item Type:	Article
Uncontrolled Keywords:	aged,biological markers,diet,genotype,humans,male,middle aged,odds ratio,phytoestrogens,polymorphism, single nucleotide,prospective studies,prostatic neoplasms,risk factors,united states,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:10
Last Modified:	25 Apr 2024 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13177
DOI:	10.1207/s15327914nc5601_5

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