Increasing antituberculosis drug resistance in the United Kingdom: analysis of national surveillance data

Kruijshaar, Michelle E., Watson, John M., Drobniewski, Francis, Anderson, Charlotte, Brown, Timothy J., Magee, John G., Smith, E. Grace, Story, Alistair and Abubakar, Ibrahim (2008) Increasing antituberculosis drug resistance in the United Kingdom: analysis of national surveillance data. British Medical Journal, 336 (7655). pp. 1231-1234. ISSN 0959-8138

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Abstract

Objective To identify recent trends in, and factors associated with, resistance to antituberculosis drugs in England, Wales, and Northern Ireland. Design Cohort of tuberculosis cases reported to the enhanced tuberculosis surveillance system matched to data on drug susceptibility and national strain typing data. Setting England, Wales, and Northern Ireland 1998-2005. Main outcome measures Unadjusted and adjusted odds ratios for drug resistance and associated factors. Proportion of multidrug resistant tuberculosis cases clustered. Results 28?620 culture confirmed cases were available for analysis. The proportion of cases resistant to isoniazid increased from 5% to 7%. Rifampicin resistance increased from 1.0% to 1.2% and multidrug resistance from 0.8% to 0.9%. Ethambutol and pyrazinamide resistance remained stable at around 0.4% and 0.6%, respectively. Regression analyses showed a significant increase in isoniazid resistance outside London (odds ratio 1.04, 95% confidence interval 1.01 to 1.07, a year, associated with changes in age (0.98, 0.98 to 0.99, a year), place of birth (1.49, 1.16 to 1.92), and ethnicity (P

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Medicine (former - to 2013)
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:10
Last Modified:	02 Feb 2024 01:50
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13057
DOI:	10.1136/bmj.39546.573067.25

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