Trypanosoma evansi: demonstration of a transferrin receptor derived from expression site-associated genes 6 and 7

Kabiri, Mostafa and Steverding, Dietmar (2001) Trypanosoma evansi: demonstration of a transferrin receptor derived from expression site-associated genes 6 and 7. Journal of Parasitology, 87 (5). pp. 1189-1191. ISSN 1937-2345

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Abstract

In Trypanosoma brucei, uptake of host transferrin is mediated by a heterodimeric, glycosylphosphatidylinositol-anchored receptor derived from the 2 expression site-associated genes 6 and 7 (ESAG6 and ESAG7). By using specific antibodies, it is shown here that T. evansi, a trypanosome species transmitted mechanically by biting flies, also expresses a transferrin receptor composed of ESAG6 and ESAG7. The cellular uptake of transferrin in T. evansi is completely inhibited with anti-T. brucei (ESAG6/7 heterodimer) antibodies. The demonstration of a functional ESAG6/7 transferrin receptor in T. evansi supports further its close relationship to T. brucei.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:10
Last Modified:	11 Aug 2023 14:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/13001
DOI:	10.1645/0022-3395(2001)087[1189:TEDOAT]2.0.CO;2

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