A systematic review of tegaserod for the treatment of irritable bowel syndrome

Jones, B. W., Moore, D. J., Robinson, S. M. and Song, F. (2002) A systematic review of tegaserod for the treatment of irritable bowel syndrome. Journal of Clinical Pharmacy and Therapeutics, 27 (5). pp. 343-352. ISSN 1365-2710

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Abstract

Aim: To assess the clinical effectiveness of tegaserod for the treatment of irritable bowel syndrome (IBS). Design: Systematic review. Setting: Six placebo-controlled, randomized controlled trials (RCTs) retrieved from electronic searches (Medline, Embase, FDA website) and hand-searching. Main outcome measures: Any outcome was accepted. Results: In a small pharmacodynamic study, tegaserod 4 mg/day accelerated orocecal transit compared with placebo, but did not affect gastric emptying rate and colonic transit. Five placebo-controlled studies evaluated Subject's Global Assessment of gastrointestinal (GI) symptoms in predominantly female patients who fulfilled Rome criteria for constipation-predominant IBS. Responder rates were higher with tegaserod 1–24 mg/day than with placebo, although it was not possible in this review to evaluate the consistency of this effect, to fully quantify the effect size, or identify patients who may gain most benefit from this treatment. Conclusion: Currently published data on tegaserod for IBS are limited (two of six RCTs published in full, four as abstracts). Tegaserod may be an appropriate treatment for occasional use for relief of GI symptoms associated with constipation-predominant IBS. Further research, comparing tegaserod with alternative treatments for GI symptoms of IBS, should help define the place of this drug in therapy.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:10
Last Modified:	16 Jul 2024 11:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/12993
DOI:	10.1046/j.1365-2710.2002.00426.x

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