Cross-sectional association between total level and type of alcohol consumption and glycosylated haemoglobin level: the EPIC-Norfolk Study

Harding, A.-H., Sargeant, L. A., Khaw, K.-T., Welch, A., Oakes, S., Luben, R. N., Bingham, S., Day, N. E. and Wareham, N. J. (2002) Cross-sectional association between total level and type of alcohol consumption and glycosylated haemoglobin level: the EPIC-Norfolk Study. European Journal of Clinical Nutrition, 56 (9). pp. 882-890. ISSN 1476-5640

Full text not available from this repository. (Request a copy)

Abstract

Objective: To investigate the association between total level and type of alcohol consumed and glycaemia. Design: Cross-sectional study. Setting: The EPIC-Norfolk Study, a population-based cohort study of diet and chronic disease. Subjects and methods: Non-diabetic men (n=2842) and women (n=3572), aged 40–78 y. Alcohol intake was assessed by self-reported questionnaire, and glycaemia measured by glycosylated haemoglobin (HbA1c). Results: Ten percent of men and 18% of women reported drinking no alcohol. Among drinkers, median alcohol intake was 8 units/week for men and 3 units/week for women. In analyses stratified by sex and adjusted for age, total energy intake, education, fruit and vegetable intake, smoking, family history of diabetes, physical activity, body mass index and waist:hip ratio, alcohol intake was inversely associated with HbA1c in men and women, although the association was stronger in women. A 1 unit/week increase in alcohol intake was associated with 0.0049% (s.e.=0.00223; P-value=0.028) and 0.017% (s.e.=0.00343; P-value <0.001) reduction in HbA1c in men and women respectively. In similar multivariate analyses, wine intake was inversely associated with HbA1c in men, and wine, spirits and beer intake were inversely associated with HbA1c in women. When also adjusted for total alcohol intake, only the association between wine intake and HbA1c in men remained significant. Conclusion: Alcohol intake was associated with lower HbA1c level, an association not explained by confounding. The distinction between type of alcohol consumed was particularly important in men.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:09
Last Modified:	24 Apr 2024 12:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/12718
DOI:	10.1038/sj.ejcn.1601408

Actions (login required)

View Item