A comparison of clinicopathological features and molecular markers in British and Nigerian women with breast cancer

Gukas, Isaac D., Girling, Anne C., Mandong, Barnabas M., Prime, Wendy, Jennings, Barbara A. ORCID: https://orcid.org/0000-0003-3792-9182 and Leinster, Samuel J. (2008) A comparison of clinicopathological features and molecular markers in British and Nigerian women with breast cancer. Clinical Medicine: Oncology, 2. pp. 347-351. ISSN 1177-9314

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Abstract

Background: Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study's aim was to look for evidence of differences in tumour biology between the two cohorts. Methods: This study compared the stage, grade and pathological expression of five immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks. Results: There were significant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no significant differences were observed for tumour grade. Conclusion: There was a significantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely influence prognosis between Nigerian and British women with breast cancer.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:09
Last Modified:	24 Sep 2024 09:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/12686
DOI:	10.4137/CMO.S474

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