Coussons, P. J., Baig, S., Fanutti, C. and Grant, R. (2005) Novel tissue remodelling roles for human recombinant erythropoietin. Biochemical Society Transactions, 33 (5). pp. 1129-1130. ISSN 0300-5127
Full text not available from this repository.Abstract
rHuEPO (recombinant human erythropoietin) is a haemopoietic growth factor and a primary regulator of erythropoiesis that is used for the treatment of chronic anaemia associated with RA (rheumatoid arthritis). Erythropoietin also appears to modulate a broad array of cellular processes, including progenitor stem-cell development, cellular integrity, angiogenesis and oxidative damage. These diverse activities suggest the exciting possibility of multiple roles for rHuEPO therapy in a variety of disorders other than RA, including cerebral ischaemia, myocardial infarction, chronic congestive heart failure and cancer. Thus it appears that rHuEPO may be a pleiotropic agent, capable of influencing tissue remodelling independently of its established erythropoietic role. Whereas these effects may be largely beneficial, dose-related side effects could have implications for the safe therapeutic use of rHuEPO and its illegal use as a performance-enhancing agent in endurance sports.
Item Type: | Article |
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Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
Depositing User: | EPrints Services |
Date Deposited: | 25 Nov 2010 11:09 |
Last Modified: | 24 Oct 2022 02:17 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/12428 |
DOI: | 10.1042/BST0331129 |
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