Are imprecise methods obscuring a relation between fat and breast cancer?

Bingham, Sheila A., Luben, Robert, Welch, Ailsa, Wareham, Nicholas, Khaw, Kay-Tee and Day, Nicholas (2003) Are imprecise methods obscuring a relation between fat and breast cancer? The Lancet, 362 (9379). pp. 212-214. ISSN 1474-547X

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Abstract

Pooled analyses of cohort studies show no relation between fat intake and breast-cancer risk. However, food-frequency questionnaire (FFQ) methods used in these studies are prone to measurement error. We assessed diet with an FFQ and a detailed 7-day food diary in 13 070 women between 1993 and 1997. We compared 168 breast-cancer cases incident by 2000 with four matched controls. Risk of breast cancer was associated with saturated-fat intake measured with the food diary (hazard ratio 1·22[95% CI 1·06–1·40], p=0·005, per quintile increase in energy-adjusted fat intake), but not with saturated fat measured with the FFQ (1·10[0·94–1·29], p=0·23). Dietary measurement error might explain the absence of a significant association between dietary fat and breastcancer risk in cohort studies.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:09
Last Modified:	19 Oct 2023 00:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/12221
DOI:	10.1016/S0140-6736(03)13913-X

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