Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases

Chabottaux, Vincent, Sounni, Nor Eddine, Pennington, Caroline J, English, William R, van den Brûle, Frédéric, Blacher, Silvia, Gilles, Christine, Munaut, Carine, Maquoi, Erik, Lopez-Otin, Carlos, Murphy, Gillian, Edwards, Dylan, Foidart, Jean-Michel and Noel, Agnès (2006) Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases. Cancer Research, 66 (10). pp. 5165-5172.

Full text not available from this repository. (Request a copy)

Abstract

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-MMP, a glycosylphosphatidylinositol–anchored protease, in breast cancer progression. Interestingly, immunohistochemical analysis shows that MT4-MMP production at protein level is strongly increased in epithelial cancer cells of human breast carcinomas compared with normal epithelial cells. Positive staining for MT4-MMP is also detected in lymph node metastases. In contrast, quantitative reverse transcription-PCR analysis reveals similar MT4-MMP mRNA levels in human breast adenocarcinomas and normal breast tissues. Stable transfection of MT4-MMP cDNA in human breast adenocarcinoma MDA-MB-231 cells does not affect in vitro cell proliferation or invasion but strongly promotes primary tumor growth and associated metastases in RAG-1 immunodeficient mice. We provide for the first time evidence that MT4-MMP overproduction accelerates in vivo tumor growth, induces enlargement of i.t. blood vessels, and is associated with increased lung metastases. These results identify MT4-MMP as a new putative target to design anticancer strategies. (Cancer Res 2006; 66(10): 5165-72)

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:38
Last Modified:	28 Mar 2025 03:58
URI:	https://ueaeprints.uea.ac.uk/id/eprint/1182
DOI:	10.1158/0008-5472.CAN-05-3012

Actions (login required)

View Item