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ToolsSteverding, D (2006) Ubiquitination of plasma membrane ectophosphatase in bloodstream forms of Trypanosoma brucei. Parasitology Research, 98 (2). pp. 157-161.
Full text not available from this repository. (Request a copy)Abstract
Bloodstream forms of Trypanosoma brucei contain plasma-membrane-integral acidic ectophosphatase. Here, it is shown by N-terminal sequencing that the ectophosphatase found in ricin-binding material was modified by ubiquitin. Three different ubiquitinated species corresponding to single, double and triple ubiquitinated forms of the enzyme were identified. Immunofluorescence studies with live bloodstream-form parasites showed that the ectophosphatase was localized in the flagellar pocket-the sole site for endocytosis in trypanosomes. As ubiquitin modification of plasma membrane proteins serves as an internalization signal, it is suggested that ubiquitinated ectophosphatase is labelled for endocytosis.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology |
| Depositing User: | EPrints Services |
| Date Deposited: | 25 Nov 2010 11:08 |
| Last Modified: | 24 Oct 2022 02:03 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/11513 |
| DOI: |
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