Ubiquitination of plasma membrane ectophosphatase in bloodstream forms of Trypanosoma brucei

Steverding, D. (2006) Ubiquitination of plasma membrane ectophosphatase in bloodstream forms of Trypanosoma brucei. Parasitology Research, 98 (2). pp. 157-161.

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Abstract

Bloodstream forms of Trypanosoma brucei contain plasma-membrane-integral acidic ectophosphatase. Here, it is shown by N-terminal sequencing that the ectophosphatase found in ricin-binding material was modified by ubiquitin. Three different ubiquitinated species corresponding to single, double and triple ubiquitinated forms of the enzyme were identified. Immunofluorescence studies with live bloodstream-form parasites showed that the ectophosphatase was localized in the flagellar pocket-the sole site for endocytosis in trypanosomes. As ubiquitin modification of plasma membrane proteins serves as an internalization signal, it is suggested that ubiquitinated ectophosphatase is labelled for endocytosis.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:08
Last Modified:	13 Oct 2025 14:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/11513
DOI:	10.1007/s00436-005-0045-3

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