Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design

Steverding, Dietmar, Caffrey, Conor R. and Sajid, Mohammed (2006) Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design. Mini-Reviews in Medicinal Chemistry, 6 (9). pp. 1025-1032. ISSN 1389-5575

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Abstract

Clan CA (papain-like) cysteine proteinases of protozoan parasites are validated targets for the rational design of new anti-parasitic chemotherapies. Peptidyl and peptidomimetic proteinase inhibitors of differing chemistries limit parasite survival in vitro and in vivo. Also, the development of activity-based affinity labels has enabled the identification and characterization of potential cysteine proteinase targets in situ. This article reviews the biology and physicochemistry of parasite proteinases and the ongoing design of peptidyl and non-peptidyl inhibitors to generate anti-parasitic compounds of greater efficacy with decreased toxicity to the host.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User:	EPrints Services
Date Deposited:	25 Nov 2010 11:08
Last Modified:	24 Oct 2022 02:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/11511
DOI:	10.2174/138955706778195207

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