Upper rim appended hybrid calixarenes via click chemistry

Bew, S.P., Brimage, R.A., L'Hermite, N. and Sharma, S.V. (2007) Upper rim appended hybrid calixarenes via click chemistry. Organic Letters, 9 (19). pp. 3713-3716.

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Abstract

We report the application of "click" chemistry for the synthesis of hybrid calixarenes appended on the upper rim with carbohydrate and N,C-protected α-amino acids. The chemoselective N- or C-deprotection of the α-amino acids and their subsequent transformation into dipeptides is described. The first example of a chemo-enzymatic synthesis on upper rim derived calix[4]arenes using trans-sialidase affords sialylated lactose calix[4]arenes. Our innovative chemo-enzymatic process paves the way for further applications. © 2007 American Chemical Society.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry

Faculty of Science > School of Chemical Sciences and Pharmacy
Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Rachel Henderson
Date Deposited: 24 Nov 2010 14:32
Last Modified: 28 Oct 2019 15:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/11017
DOI: 10.1021/ol071047t

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