N- vs. O-alkylation in 2(1H)-quinolinone derivatives

Guo, Zhao-Xia, Cammidge, Andrew N. ORCID: https://orcid.org/0000-0001-7912-4310, McKillop, Alexander and Horwell, David C. (1999) N- vs. O-alkylation in 2(1H)-quinolinone derivatives. Tetrahedron Letters, 40 (38). pp. 6999-7002. ISSN 0040-4039

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Abstract

N- vs O-alkylation reactions of 8-benzyloxy-2(1H)-quinolinone have been investigated using both classical and phase transfer conditions. The influence of reaction solvents/conditions was found to have a dramatic effect on selectivity, with opposite trends to that observed for 2-pyridone alkylation.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Chemistry of Light and Energy
Depositing User:	Rachel Smith
Date Deposited:	25 Nov 2010 13:42
Last Modified:	27 Sep 2024 19:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/11001
DOI:	10.1016/S0040-4039(99)01422-7

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