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Fung, C. Y. Eleanor, Brearley, Charles A. 
ORCID: https://orcid.org/0000-0001-6179-9109, Farndale, Richard W. and Mahaut-Smith, Martyn P.
(2005)
A major role for P2X(I) receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets.
Thrombosis and Haemostasis, 94 (1).
pp. 37-40.
Abstract
In the platelet, ATP-gated P2X1 receptors have been reported to amplify functional responses to collagen,however the relative importance of early Ca2+ mobilisation events is unknown. We now report that selective desensitisation of P2X1 receptor activity leads to a major reduction in the initial intracellular Ca2+ responses to a wide range of collagen concentrations (0.25–2 µ g ml-1). Peak [Ca2+] i increases were reduced to 8.5 and 55% of control, and the maximum rate of rise was reduced to 12 and 33% of control,at low and high collagen concentrations,respectively. This P2X 1 -dependent acceleration and enhancement of collagen-stimulated Ca2+ responses was not observed in the absence of extracellular Ca2+.These results demonstrate a major role for ATP-gated Ca2+ influx in the early collagen-evoked Ca2+ signals and can at least partly explain the important contribution of P2X1 receptors to arterial thrombosis.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Plant Sciences Faculty of Science > Research Groups > Molecular Microbiology |
| Depositing User: | EPrints Services |
| Date Deposited: | 01 Oct 2010 13:37 |
| Last Modified: | 24 Oct 2022 02:10 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/1036 |
| DOI: | 10.1160/TH04-11-0732 |
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