Tools
ToolsCatelas, Isabelle, Lehoux, Eric A., Ning, Zhibin, Figeys, Daniel, Baskey, Stephen J. and Beaulé, Paul E. (2018) Differential proteomic analysis of synovial fluid from hip arthroplasty patients with a pseudotumor vs. Periprosthetic osteolysis. Journal of Orthopaedic Research, 36 (7). pp. 1849-1859. ISSN 0736-0266
Full text not available from this repository. (Request a copy)Abstract
Adverse tissue reactions to metal implants, including pseudotumors, can compromise implant functionality and survivorship. The identification of specific proteins in the synovial fluid (SF) of hip arthroplasty patients with a pseudotumor may lead to a better understanding of the underlying pathomechanisms. The objective of the present study was to compare the protein content of SF from patients with a short-term metal-on-metal hip implant associated with a pseudotumor and patients with a long-term metal-on-polyethylene hip implant associated with periprosthetic osteolysis. Discovery proteomics was used to identify differentially abundant proteins in albumin-depleted SF. In toto, 452 distinct proteins (present in at least half of the patients in one or both groups) were identified. Thirty of these 452 proteins were differentially abundant between the two groups, including two potential biomarkers: 6-phosphogluconate dehydrogenase (which plays a major protective role against oxidative stress) for the pseudotumor group, and scavenger receptor cysteine-rich type 1 protein M130 (which is involved in low-grade inflammation) for the periprosthetic osteolysis group. Other differentially abundant proteins identified suggest the presence of an adaptive immune response (particularly a type-IV hypersensitivity reaction), necrosis, and greater oxidative stress in patients with a pseudotumor. They also suggest the presence of an innate immune response, oxidative stress, tissue remodeling, and apoptosis in both patient groups, although differences in the specific proteins identified in each group point to differences in the pathomechanisms. Overall, results provide insights into the molecular mechanisms underlying metal-related pseudotumors and periprosthetic osteolysis, and may ultimately help elucidate pseudotumor etiology and assess the risk that asymptomatic pseudotumors will develop into an aggressive lesion.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. |
| Uncontrolled Keywords: | hip implant,pathomechanisms,proteomics,pseudotumor,synovial fluid,orthopedics and sports medicine ,/dk/atira/pure/subjectarea/asjc/2700/2732 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 26 Mar 2026 08:30 |
| Last Modified: | 29 Mar 2026 06:35 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/102587 |
| DOI: | 10.1002/jor.23858 |
Actions (login required)
 |
View Item |