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ToolsZhang, Xu and Figeys, Daniel (2019) Perspective and Guidelines for Metaproteomics in Microbiome Studies. Journal of Proteome Research, 18 (6). pp. 2370-2380. ISSN 1535-3893
Full text not available from this repository. (Request a copy)Abstract
The microbiome is emerging as a prominent factor affecting human health, and its dysbiosis is associated with various diseases. Compositional profiling of microbiome is increasingly being supplemented with functional characterization. Metaproteomics is intrinsically focused on functional changes and therefore will be an important tool in those studies of the human microbiome. In the past decade, development of new experimental and bioinformatic approaches for metaproteomics has enabled large-scale human metaproteomic studies. However, challenges still exist, and there remains a lack of standardizations and guidelines for properly performing metaproteomic studies on human microbiome. Herein, we provide a perspective of recent developments, the challenges faced, and the future directions of metaproteomics and its applications. In addition, we propose a set of guidelines/recommendations for performing and reporting the results from metaproteomic experiments for the study of human microbiomes. We anticipate that these guidelines will be optimized further as more metaproteomic questions are raised and addressed, and metaproteomic applications are published, so that they are eventually recognized and applied in the field.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2019 American Chemical Society. |
| Uncontrolled Keywords: | bioinformatics,guidelines,metaproteomics,microbiome,multiomics,post-translational modification,standards,workflow,chemistry(all),biochemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1600 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 26 Mar 2026 08:30 |
| Last Modified: | 29 Mar 2026 06:35 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/102583 |
| DOI: | 10.1021/acs.jproteome.9b00054 |
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