Metaproteomic and Metabolomic Approaches for Characterizing the Gut Microbiome

Peters, Danielle L., Wang, Wenju, Zhang, Xu, Ning, Zhibin, Mayne, Janice and Figeys, Daniel (2019) Metaproteomic and Metabolomic Approaches for Characterizing the Gut Microbiome. Proteomics, 19 (16). ISSN 1615-9853

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Abstract

The gut microbiome has been shown to play a significant role in human healthy and diseased states. The dynamic signaling that occurs between the host and microbiome is critical for the maintenance of host homeostasis. Analyzing the human microbiome with metaproteomics, metabolomics, and integrative multi-omics analyses can provide significant information on markers for healthy and diseased states, allowing for the eventual creation of microbiome-targeted treatments for diseases associated with dysbiosis. Metaproteomics enables functional activity information to be gained from the microbiome samples, while metabolomics provides insight into the overall metabolic states affecting/representing the host–microbiome interactions. Combining these functional -omic platforms together with microbiome composition profiling allows for a holistic overview on the functional and metabolic state of the microbiome and its influence on human health. Here the benefits of metaproteomics, metabolomics, and the integrative multi-omic approaches to investigating the gut microbiome in the context of human health and diseases are reviewed.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Uncontrolled Keywords:	mass spectrometry,metabolomics,metaproteomics,microbiome,multi-omics,biochemistry,molecular biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	26 Mar 2026 08:30
Last Modified:	29 Mar 2026 06:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/102581
DOI:	10.1002/pmic.201800363

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