Non-Pharmacological Interventions for Managing Fatigue in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Alageel, Sarah, Hibberd, Jane and Deane, Katherine H. O. (2026) Non-Pharmacological Interventions for Managing Fatigue in Parkinson’s Disease: A Systematic Review and Meta-Analysis. Parkinsonism & Related Disorders, 14. ISSN 1353-8020

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Abstract

Fatigue is a prevalent and disabling non-motor symptom in Parkinson’s disease, yet effective management strategies remain limited. This systematic review and meta-analysis evaluated the efficacy of non-pharmacological interventions targeting fatigue in people with Parkinson’s disease. Five randomised controlled trials (n = 270) were included. Exercise-based interventions demonstrated a significant reduction in fatigue, although with substantial heterogeneity, while acupuncture showed no significant effect compared with sham controls. The overall certainty of evidence ranged from low to moderate. Findings highlight the need for high-quality, adequately powered trials and support further exploration of multimodal and self-management approaches for fatigue in Parkinson’s disease.

Item Type:	Article
Uncontrolled Keywords:	parkinson's disease,fatigue,non-pharmacological interventions,systematic review,meta-analysis,exercise,acupuncture
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups:	Faculty of Arts and Humanities > Research Groups > Gender and Its Intersections Faculty of Medicine and Health Sciences > Research Centres > Institute for Volunteering Research Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Centres > Mental Health and Social Care (fka Lifespan Health)
Depositing User:	LivePure Connector
Date Deposited:	24 Mar 2026 15:30
Last Modified:	24 Mar 2026 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/102570
DOI:	10.1016/j.prdoa.2026.100434

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