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ToolsZhang, Ailing, Wu, Qing, Mayne, Janice, Ning, Zhibin, Qin, Hongye, Dewar, Alexander and Figeys, Daniel (2026) Microbiome-dependent functional responses to structurally distinct oligosaccharides revealed by metaproteomics. npj Biofilms and Microbiomes, 12 (1). ISSN 2055-5008
Full text not available from this repository. (Request a copy)Abstract
Dietary oligosaccharides are prebiotics that fuel gut microbes, but individual microbiomes may respond differently depending on oligosaccharide structures as well as microbiome composition and function. The extent to which specific gut microbial communities exhibit personalized functional responses to distinct oligosaccharides remains underexplored. We applied a standardized ex vivo microbiome culture, called RapidAIM, coupled with metaproteomics to examine how six structurally diverse oligosaccharides affect the gut microbiota functional response. Our study shows that while human gut microbiomes share some commonalities in utilizing oligosaccharides (e.g. prioritizing dietary fibers over mucin), the fine-scale metabolic and taxonomic responses are highly individualized. Such findings underscore the importance of considering personal microbiome profiles when predicting the outcome of prebiotic interventions. In a broader context, our metaproteomic approach provides a framework for identifying optimal prebiotic choices tailored to individual microbiomes. Ultimately, understanding these personalized responses could inform precision nutrition strategies.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability: The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE53. partner repository with the dataset identifier: PXD064733. |
| Uncontrolled Keywords: | biotechnology,microbiology,applied microbiology and biotechnology ,/dk/atira/pure/subjectarea/asjc/1300/1305 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Mar 2026 12:30 |
| Last Modified: | 22 Mar 2026 07:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/102505 |
| DOI: | 10.1038/s41522-025-00881-w |
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