Extracellular ATP and innate immune cells

Lopez-Castejon, Gloria and Stokes, Leanne (2026) Extracellular ATP and innate immune cells. In: From Neurotransmission to Cancer Therapy Molecular Mediators in Health and Disease: How Cells Communicate. Academic Press. ISBN 978-0-443-30250-3

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Abstract

The innate immune system comprises multiple cell types involved in many functions, including phagocytosis of foreign material and organisms, secretion of mediators to orchestrate the immune response, and antimicrobial killing mechanisms. Extracellular adenosine triphosphate (eATP) is a well-known danger signal in the body, alerting innate immune cells to damage, and this is sensed by a multitude of P2 receptors from the P2X and P2Y subclasses. In this chapter, we review what is known about the P2 receptors expressed on monocytes, macrophages, dendritic cells, innate lymphoid cells, neutrophils, basophils, eosinophils, and mast cells, and how eATP can regulate their main functional responses. We discuss key signaling events modulated by eATP that lead to activation of inflammatory pathways, and how this impacts inflammatory diseases.

Item Type:	Book Section
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
UEA Research Groups:	Faculty of Science > Research Groups > Pharmacology and Biological Chemistry
Depositing User:	LivePure Connector
Date Deposited:	18 Mar 2026 10:30
Last Modified:	18 Mar 2026 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/102397
DOI:	10.1016/B978-0-443-30250-3.00014-X

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