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ToolsSchunkert, Heribert, Di Angelantonio, Emanuele, Inouye, Michael, Patel, Riyaz S., Ripatti, Samuli, Widen, Elisabeth, Sanderson, Saskia C., Kaski, Juan Pablo, McEvoy, John W., Vardas, Panos, Wood, Angela, Aboyans, Victor, Vassiliou, Vassilios S., Visseren, Frank L. J., Lopes, Luis R., Elliott, Perry and Kavousi, Maryam (2025) Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive Cardiology. European Heart Journal, 46 (15). pp. 1372-1383. ISSN 0195-668X
Full text not available from this repository. (Request a copy)Abstract
Genome-wide association studies have revealed hundreds of genetic variants associated with cardiovascular diseases (CVD). Polygenic risk scores (PRS) can capture this information in a single metric and hold promise for use in CVD risk prediction. Importantly, PRS information can reflect the causally mediated risk to which the individual is exposed throughout life. Although European Society of Cardiology guidelines do not currently advocate their use in routine clinical practice, PRS are commercially available and increasingly sought by clinicians, health systems, and members of the public to inform personalized health care decision-making. This clinical consensus statement provides an overview of the scientific basis of PRS and evidence to date on their role in CVD risk prediction for the purposes of disease prevention. It provides the reader with a summary of the opportunities and challenges for implementation and identifies current gaps in supporting evidence. The document also lays out a potential roadmap by which the scientific and clinical community can navigate any future transition of PRS into routine clinical care. Finally, clinical scenarios are presented where information from PRS may hold most value and discuss organizational frameworks to enable responsible use of PRS testing while more evidence is being generated by clinical studies.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2025 The European Society of Cardiology. All rights reserved. |
| Uncontrolled Keywords: | genetics,polygenic risk score,risk prediction,cardiology and cardiovascular medicine,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2705 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 12 Mar 2026 11:30 |
| Last Modified: | 15 Mar 2026 07:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/102325 |
| DOI: | 10.1093/eurheartj/ehae649 |
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