An emerging field: Post-translational modification in microbiome

Duan, Haonan, Zhang, Xu and Figeys, Daniel (2023) An emerging field: Post-translational modification in microbiome. Proteomics, 23 (3-4). pp. 1-16. ISSN 1615-9853

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Abstract

Post-translational modifications (PTMs) play an essential role in most biological processes. PTMs on human proteins have been extensively studied. Studies on bacterial PTMs are emerging, which demonstrate that bacterial PTMs are different from human PTMs in their types, mechanisms and functions. Few PTM studies have been done on the microbiome. Here, we reviewed several studied PTMs in bacteria including phosphorylation, acetylation, succinylation, glycosylation, and proteases. We discussed the enzymes responsible for each PTM and their functions. We also summarized the current methods used to study microbiome PTMs and the observations demonstrating the roles of PTM in the microbe-microbe interactions within the microbiome and their interactions with the environment or host. Although new methods and tools for PTM studies are still needed, the existing technologies have made great progress enabling a deeper understanding of the functional regulation of the microbiome. Large-scale application of these microbiome-wide PTM studies will provide a better understanding of the microbiome and its roles in the development of human diseases.

Item Type:	Article
Uncontrolled Keywords:	bioinformatics,cell biology,metaproteomics,microbiology,microbiome,post-translational modifications,biochemistry,molecular biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	06 Mar 2026 16:30
Last Modified:	09 Mar 2026 16:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/102248
DOI:	10.1002/pmic.202100389

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