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ToolsOyston, Charlotte and Baker, Philip N. (2017) Therapeutic strategies for the prevention and treatment of pre-eclampsia and intrauterine growth restriction. Obstetrics, Gynaecology and Reproductive Medicine, 27 (1). pp. 22-28. ISSN 1751-7214
Full text not available from this repository. (Request a copy)Abstract
Intrauterine growth restriction and pre-eclampsia are common pregnancy complications that contribute significantly to maternal and perinatal morbidity and mortality, and long term health outcomes. The underlying aetiology of these conditions involves placental under perfusion and placental ischaemia. Most prophylactic and treatment measures for these conditions are hypothesised to have effect through improved placental perfusion, or reduced oxidative stress and subsequent placental damage. However, while many therapies have biologic plausibility, there is a lack of high quality evidence that they substantially improve important outcomes such as birth weight, prematurity, mortality or serious morbidity. This review will describe and evaluate therapies currently available in clinical practice for the prevention and treatment of pre-eclampsia and intrauterine growth restriction, and outline some promising new therapies, which may change the way these conditions are managed in the future.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2016 Elsevier Ltd |
| Uncontrolled Keywords: | fetal growth restriction,pre-eclampsia,pregnancy complications,pregnancy outcome,prevention,reproductive medicine,obstetrics and gynaecology ,/dk/atira/pure/subjectarea/asjc/2700/2743 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Mar 2026 16:30 |
| Last Modified: | 02 Mar 2026 16:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/102136 |
| DOI: | 10.1016/j.ogrm.2016.12.001 |
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