Imbalance between proliferation and apoptosis−related impaired GPR30 expression is involved in preeclampsia

Li, Jianxin; Chen, Zhu; Zhou, Xiaobo; Shi, Shuming; Qi, Hongbo; Baker, Philip N.; Zhang, Hua

doi:10.1007/s00441-016-2466-y

Imbalance between proliferation and apoptosis−related impaired GPR30 expression is involved in preeclampsia

Tools

Li, Jianxin, Chen, Zhu, Zhou, Xiaobo, Shi, Shuming, Qi, Hongbo, Baker, Philip N. and Zhang, Hua (2016) Imbalance between proliferation and apoptosis−related impaired GPR30 expression is involved in preeclampsia. Cell and Tissue Research, 366 (2). pp. 499-508. ISSN 0302-766X

Full text not available from this repository. (Request a copy)

Abstract

The proliferation and apoptosis of cells in the placenta play a critical role in preeclampsia (PE) in which estrogen has been implicated via estrogen receptors (ERs). A novel ER, G-protein-coupled receptor 30 (GPR30), has recently been shown to be involved in PE. We investigated the basic levels of proliferation and apoptosis in normal placentae and placentae with PE and compared GPR30 expression levels between the two groups. We demonstrated that low GPR30 expression levels, more apoptosis, and less proliferation were associated with PE. Moreover, our in vitro study showed that both the selective GPR30 agonist G1 and the general ER agonist 17-β-estradiol were able to protect the placenta from hypoxia-reoxygenation injuries, resulting in decreased apoptosis and increased proliferation. Furthermore, this protective effect was abolished by the addition of the selective GPR30 inhibitor G15. These results provide evidence that (1) GPR30 is involved in regulating cell proliferation and apoptosis; (2) pharmacologic upregulation of GPR30 is beneficial for PE management; (3) GPR30 may therefore be an interventional target for pregnancies complicated by PE.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2016, Springer-Verlag Berlin Heidelberg.
Uncontrolled Keywords:	apoptosis,gpr30,placenta,preeclampsia,proliferation,pathology and forensic medicine,histology,cell biology ,/dk/atira/pure/subjectarea/asjc/2700/2734
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	02 Mar 2026 15:30
Last Modified:	02 Mar 2026 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/102131
DOI:	10.1007/s00441-016-2466-y

Actions (login required)

View Item