Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies

Liao, Shutan, Vickers, Mark H., Taylor, Rennae S., Jones, Beatrix, Fraser, Mhoyra, McCowan, Lesley M.E., Baker, Philip N. and Perry, Jo K. (2017) Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies. Growth Factors, 34 (5-6). pp. 203-209. ISSN 0897-7194

Full text not available from this repository. (Request a copy)

Abstract

To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for-gestational-age (LGA) and small-for-gestational-age (SGA) cases in a nested case-control study. Maternal serum samples were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Serum hormone concentrations were determined by ELISA. We found that maternal serum GH-V concentrations at 20 weeks of gestation in LGA pregnancies were significantly higher than in AGA and SGA pregnancies. Maternal GH-V concentrations were positively correlated to birth weights and customized birth weight centiles, while IGFBP-1 concentrations were inversely related to birth weights and customized birth weight centiles. Our findings suggest that maternal serum GH-V and IGFBP-1 concentrations at 20 weeks' gestation are associated with fetal growth.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Uncontrolled Keywords:	birth weight,large-for-gestational-age,placental growth hormone,pregnancy,endocrinology,clinical biochemistry,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1310
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	02 Mar 2026 15:30
Last Modified:	02 Mar 2026 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/102130
DOI:	10.1080/08977194.2016.1273223

Actions (login required)

View Item